产品货号：
Z34935
中文名称：
MALT1抗体
英文名称：
Anti-MALT1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MALT1 Antibody |
| 指标别名 | MALT1;MLT;MLT1;Paracaspase |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,ICC/IF,FCM |
| 基因名称 | MALT1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human MALT1 Enhances BCL10-induced activation of NF-kappa-B.Involved in nuclear export of BCL10.Binds to TRAF6,inducing TRAF6 oligomerization and activation of its ligase activity.Has ubiquitin ligase activity.MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. |
| 实际分子量 | 92KD |
| 成分 | Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | MALT1(Mucosa-associated lymphoid tissue lymphoma translocation protein 1),also called MLT or PARACASPASE,is a protein that in humans is encoded by the MALT1 gene.This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3(also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas.Dierlamm et al.(1999) and Akagi et al.(1999) mapped the MALT1 gene to chromosome 18q21.Using mouse models,Ruland et al.(2003) demonstrated that MALT1 is essential for T-cell activation,proliferation,and IL2 production in response to T-cell receptor ligation and strictly required for signal-specific NF-kappa-B(NFKB) activation induced by the T-cell receptor but not TNF-alpha or IL1 signaling.MALT1 operates downstream of BCL10,controls the catalytic activity of the canonical I-kappa-B kinase complex,and regulates the signaling of JNK and p38 MAP kinases. |
| Uniprot ID | Q9UDY8 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunocytochemistry/Immunofluorescence(ICC/IF) 1:20～100 Flow cytometry (FCM) 1:20 |
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